Enabling Machine Learning Across Heterogeneous Sensor Networks with Graph Autoencoders

Machine Learning (ML) has been applied to enable many life-assisting appli-cations, such as abnormality detection and emdergency request for the soli-tary elderly. However, in most cases machine learning algorithms depend on the layout of the target Internet of Things (IoT) sensor network. Hence, to deploy an application across Heterogeneous Sensor Networks (HSNs), i.e. sensor networks with different sensors type or layouts, it is required to repeat the process of data collection and ML algorithm training. In this paper, we introduce a novel framework leveraging deep learning for graphs to enable using the same activity recognition system across HSNs deployed in differ-ent smart homes. Using our framework, we were able to transfer activity classifiers trained with activity labels on a source HSN to a target HSN, reaching about 75% of the baseline accuracy on the target HSN without us-ing target activity labels. Moreover, our model can quickly adapt to unseen sensor layouts, which makes it highly suitable for the gradual deployment of real-world ML-based applications. In addition, we show that our framework is resilient to suboptimal graph representations of HSNs

FITsense: employing multi-modal sensors in smart homes to predict falls.

As people live longer, the increasing average age of the population places additional strains on our health and social services. There are widely recognised benefits to both the individual and society from supporting people to live independently for longer in their own homes. However, falls in particular have been found to be a leading cause of the elderly moving into care, and yet surprisingly preventative approaches are not in place; fall detection and rehabilitation are too late. In this paper we present FITsense, which is building a Smart Home environment to identify increased risk of falls for residents, and so allow timely interventions before falls occurs. An ambient sensor network, installed in the Smart Home, identifies low level events taking place which is analysed to generate a resident’s profile of activities of daily living (ADLs). These ADL profiles are compared to both the resident’s typical profile and to known “risky” profiles to allow evidence-driven intervention recommendations. Human activity recognition to identify ADLs from sensor data is a key challenge. Here we compare a windowing-based and a sequence-based event representation on four existing datasets. We find that windowing works well, giving consistent performance but may lack sufficient granularity for more complex multi-part activities

Anomaly detection in elderly daily behavior in ambient sensing environments

Current ubiquitous computing applications for smart homes aim to enhance people’s daily living respecting age span. Among the target groups of people, elderly are a population eager for “choices for living arrangements”, which would allow them to continue living in their homes but at the same time provide the health care they need. Given the growing elderly population, there is a need for statistical models able to capture the recurring patterns of daily activity life and reason based on this information. We present an analysis of real-life sensor data collected from 40 different households of elderly people, using motion, door and pressure sensors. Our objective is to automatically observe and model the daily behavior of the elderly and detect anomalies that could occur in the sensor data. For this purpose, we first introduce an abstraction layer to create a common ground for home sensor configurations. Next, we build a probabilistic spatio-temporal model to summarize daily behavior. Anomalies are then defined as significant changes from the learned behavioral model and detected using a cross-entropy measure. We have compared the detected anomalies with manually collected annotations and the results show that the presented approach is able to detect significant behavioral changes of the elderly

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Chagas Disease is caused by kinetoplastid protozoa Trypanosoma cruzi, whose sterols resemble those of fungi, in both composition and biosynthetic pathway. Azole inhibitors of sterol 14α-demethylase (CYP51), such as fluconazole, itraconazole, voriconazole, and posaconazole, successfully treat fungal infections in humans. Efforts have been made to translate anti-fungal azoles into a second-use application for Chagas Disease. Ravuconazole and posaconazole have been recently proposed as candidates for clinical trials with Chagas Disease patients. However, the widespread use of posaconazole for long-term treatment of chronic infections may be limited by hepatic and renal toxicity, a requirement for simultaneous intake of a fatty meal or nutritional supplement to enhance absorption, and cost. To aid our search for structurally and synthetically simple CYP51 inhibitors, we have determined the crystal structures of the CYP51 targets in T. cruzi and T. brucei, both bound to the anti-fungal drugs fluconazole or posaconazole. The structures provide a basis for a design of new drugs targeting Chagas Disease, and also make it possible to model the active site characteristics of the highly homologous Leishmania CYP51. This work provides a foundation for rational synthesis of new therapeutic agents targeting the three kinetoplastid parasites

Latent feature learning for activity recognition using simple sensors in smart homes

[[abstract]]Activity recognition is an important step towards monitoring and evaluating the functional health of an individual, and it potentially promotes human-centric ubiquitous applications in smart homes particularly for senior healthcare. The nature of human activity characterized by a high degree of complexity and uncertainty, however, poses a great challenge to the design of good feature representations and the optimization of classifiers towards building a robust model for human activity recognition. In this study, we propose to exploit deep learning techniques to automatically learn high-level features from the binary sensor data under the assumption that there exist discriminative latent patterns inherent in the simple low-level features. Specifically, we extract high-level features with a stacked autoencoder that has a deep and hierarchy architecture, and combine feature learning and classifier construction into a unified framework to obtain a jointly optimized activity recognizer. Besides, we investigate two different original feature representations of the sensor data for latent feature learning. To evaluate the performance of the proposed method, we conduct extensive experiments on three publicly available smart home datasets, and compare it with a range of shallow models in terms of time-slice accuracy and class accuracy. Experimental results show that our proposed model achieves better recognition rates and generalizes better across different original feature representations, indicating its applicability to the real-world activity recognition.[[notice]]補正完